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     Post subject: duloxetine cymbalta synaptic transmission
    PostPosted: Sun Oct 25, 2009 8:41 am 
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    Joined: Thu Sep 24, 2009 12:19 pm
    Posts: 35332
    Location: Austria
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    Cymbalta (DULOXETINE) is an antidepressant recently approved by the FDA that has also been approved to treat peripheral neuropathy. People who suffer from depression will often experience pain; people with depression are more sensitive to pain, and treating depression improves one’s threshold for pain. Cymbalta not only treats the emotional effects of depression, but the physical pain of depression as well.

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    п»їBefore taking Cymbalta

    Do not use Cymbalta together with thioridazine (Mellaril), or an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam). Serious and sometimes fatal reactions can occur when these medicines are taken with Cymbalta. You must wait at least 14 days after stopping an MAO inhibitor before you can take Cymbalta. After you stop taking Cymbalta, you must wait at least 5 days before you start taking an MAOI. Do not use this medication if you are allergic to duloxetine, or if you have untreated or uncontrolled glaucoma.

    Before taking Cymbalta, tell your doctor if you are allergic to any drugs, or if you have:
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    a history of drug abuse or suicidal thoughts.

    If you have any of these conditions, you may need a dose adjustment or special tests to safely take Cymbalta.

    You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

    Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

    FDA pregnancy category C. Cymbalta may be harmful to an unborn baby, and may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment. Duloxetine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

    Older adults may be more sensitive to the side effects of this medication.

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     Post subject: does accutane ever not work
    PostPosted: Wed Dec 30, 2009 4:59 pm 
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    Joined: Thu Sep 24, 2009 12:19 pm
    Posts: 35332
    Location: Austria
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    Why should Accutane not be prescribed?

    If Accutane gives you an allergic reaction, you will not be able to use it.

    If you are a woman of childbearing age, you should not take Accutane if you are pregnant, if you think there is a possibility you might get pregnant during the treatment, or if you are unable to keep coming back to the doctor for monthly checkups, including pregnancy testing.


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    Stop taking Accutane and notify your doctor immediately at the first sign of a skin rash or any other allergic reaction. Although they are rare, serious and even fatal allergic reactions have been known to occur.

    When you first start taking Accutane, it is possible that your acne will get worse before it starts to get better.

    Accutane may cause depression or other mental problems such as: mood swings, aggression, sadness, hopelessness, loss of pleasure, fatigue, difficulty concentrating, change in sleep patterns, restlessness, and irritability. In rare cases, it has prompted thoughts of suicide. If you begin to feel depressed or become troubled by suicidal thoughts, contact your doctor immediately.

    Before starting Accutane therapy, all patients must sign a consent form noting that they are aware of the possibility of mental side effects, the danger of birth defects, and the need for certain other precautions.

    If you are a woman of childbearing age and you are considering taking Accutane, you will be given both spoken and written warnings (the iPLEDGE program) about the importance of avoiding pregnancy during the treatment. You will also be asked to sign a second consent form noting that:
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    If you get pregnant while taking Accutane, your baby will be at high risk for birth defects;
    If you take Accutane, you must use 2 effective forms of birth control from 1 month before the start of treatment through 1 month after the end of treatment;
    You must have 2 negative pregnancy tests (one just before starting Accutane therapy), and must be tested every month during therapy;
    You may participate in a program that includes an initial free pregnancy test and birth control counseling session;
    If you become pregnant, you must immediately stop taking Accutane and see your doctor;
    You have read and understood the Accutane patient brochure and asked your doctor any questions you had;
    You have been invited to participate in a survey of women being treated with Accutane.

    Some people taking Accutane, including some who simultaneously took tetracycline, have experienced headache, nausea, and visual disturbances caused by increased pressure within the skull. Avoid taking tetracycline while using Accutane. See a doctor immediately if you have these symptoms; if the doctor finds swelling of the optic nerve at the back of your eye, you must stop taking Accutane at once and see a neurologist for further care.

    Be careful driving at night. Some people have experienced a sudden decrease in night vision.

    Accutane affects the body's processing of fats and sugars. It should be used cautiously by people with diabetes, excess weight, high triglyceride or cholesterol levels, or a tendency to drink too much alcohol. If you have any of these conditions, your doctor will monitor you closely during Accutane therapy.

    You may not be able to tolerate your contact lenses during and after your therapy with Accutane.

    You should stop taking Accutane immediately if you have abdominal pain, bleeding from the rectum, or severe diarrhea. You may have an inflammatory disease of the bowel.

    You should not donate blood during your therapy with Accutane and for a month after you stop taking it.

    You may become more sensitive to light while taking Accutane. Try to stay out of the sun as much as possible.

    You should not use wax hair removal treatments or skin resurfacing procedures (dermabrasion, laser treatments) while taking Accutane or for 6 months after completing therapy.

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